January – February 2020: Best of the Blue Ridge

first_imgFeatures New 2020 tunes on the horizon; Sturgill Simpson plays Southern arenas Readers pick their favorite race, faces, and places in the region. A major climate report offers a bleak forecast for the ski industry.  Local Favorites: Gear made in the Blue Ridge The Slopes on a Budget TRAIL MIX Boat Rock bouldering competition – R.I.P. Jake Burton Carpenter – Scenes from North Carolina’s Shut-In Ridge Trail Race – Gear made in the Blue Ridge – Frigid running in Pennsylvania – Brewery makes edible packaging THE GOODS On the Cover Thirty-three years after publishing Southern Snow: The Winter Guide to Dixie, author Randy Johnson reflects on the cult classic, which has just been reissued with a second edition.  Quick Hits LWCF: Four letters that every outdoor adventurer should know 2020 RACE AND EVENT GUIDE Best of the Blue Ridge Photo by Justin Potter, WINNER of the BLUE RIDGE OUTDOORS COVER PHOTO CONTEST. Determined to get his kids on the mountain, an avid skier shares tips for making resort runs affordable.  “Unviable” Snow in the South Perspective Departments Justin set out to capture the Rhododendrons blooming but was treated to one of the most beautiful sunrises of the year!last_img read more

Spain Requests Extradition of ETA Suspect from Cuba

first_img Spain said on October 14, it will request the extradition from Cuba of an alleged member of the Basque separatist group ETA who allegedly sought explosives training from Colombian rebel group the Revolutionary Armed Forces of Colombia (FARC). Venezuelan authorities detained Jose Ignacio Echarte and two other suspected ETA members in August after the boat they were in ran aground on the Venezuelan island of Los Roques, just south of Cuba. They then turned him over to Cuban authorities. The extradition request is based on information found on computer archives seized from three ETA leaders in Paris in 1999, which allegedly showed Echarte had requested permission to work with explosives, Spain’s Justice Ministry said in a statement. “Echarte requested permission to take part, with several members of FARC, in the launch of grenades and mortars in the Colombian-Venezuelan jungle,” it said. Spain’s National Court Judge Eloy Velasco, who has been investigating suspected ties between ETA and FARC, had issued an international arrest warrant for Echarte and requested his extradiction from Cuba. The government approved Justice Minister Francisco Caamaño’s decision to file the extradition request for Echarte at a cabinet meeting on October 14, the Justice Ministry statement said. ETA is held responsible for 829 deaths in its battle to carve out an independent Basque homeland in northern Spain and southwestern France. FARC is the oldest and largest leftist guerilla group in Colombia with an estimated 8,000 combatants. By Dialogo October 18, 2011last_img read more

Face Masks That You Can Wear to Show Off Your Personality

first_imgWith that in mind, we found so many face masks that are bound to be solid additions to your collection. While it may be uncomfortable at times, wearing a mask is a crucial action in order to help our communities stay safe during this trying time. Face masks may not fully protect you or others from contracting every type of viral infection, but wearing an appropriate covering can significantly reduce the rate of which illness can spread. Do your part and pick out one of the personality-filled masks below, or grab one as a stocking stuffer for the holiday season! Us Weekly has affiliate partnerships so we may receive compensation for some links to products and services.Please note: Information below is not intended to diagnose, treat, cure or prevent any disease or health condition.- Advertisement – See tips and information from the CDC.It’s no secret that face masks have become a daily accessory. When the COVID-19 pandemic began, we had a small selection to choose from. In fact, we were all clamoring for any type of face covering that we could get — while making sure medical-grade options were reserved for frontline workers who needed them most. Since then, the offering has evolved. Brands have developed reusable cloth masks that are seriously stylish, and can show off our personalities in the process. Honestly, some of them are actually quite funny — and can potentially put a (hidden) smile on someone’s face!Popular face masks today range from fun graphic prints, to political or personal statements, to funky designs. If we have to wear a mask — as we all should, per the current CDC guidelines — then why not at least try to have a little fun with the situation?- Advertisement –center_img – Advertisement –last_img read more

Avian flu confirmed in three Indonesian deaths

first_imgJul 20, 2005 (CIDRAP News) – Indonesian officials confirmed today that a man and his two young daughters who died earlier this month had H5N1 avian influenza, though they had had no known contact with infected poultry.The 38-year-old man and his daughters, aged 1 and 9, were the first Indonesians to die of the illness. Indonesia has had a number of poultry outbreaks but only one previous human case, an asymptomatic one reported last month.Indonesian Health Minister Siti Fadillah Supari said laboratory tests in Hong Kong on samples from the man and one daughter confirmed that they had the virus, according to news services.Supari said it could be concluded that all three died of the illness. “We don’t distinguish between the three,” an Agence France-Presse (AFP) report quoted her as saying.Though there was no evidence that the three victims had been exposed to infected poultry, Supari said person-to-person transmission of the virus seemed unlikely, according to an Associated Press (AP) report. She said the virus strain that killed them had not mutated.”It’s the conventional H5N1 virus and not a new strain,” Bloomberg News quoted Supari as saying.Health agencies fear that the H5N1 virus will evolve so as to allow easy person-to-person transmission, leading to a pandemic. Only one probable instance of person-to-person transmission has been documented so far, that of an 11-year-old Thai girl who apparently passed the virus to her mother and an aunt last September. Person-to-person transmission was also suspected in some family case clusters in Vietnam this year.The Indonesian cases bring CIDRAP’s unofficial count of H5N1 deaths since late 2003 to 59, including 40 in Vietnam, 12 in Thailand, and 4 in Cambodia. Adding the three deaths to the World Health Organization’s current numbers yields a total of 111 cases with 57 deaths. The WHO has not yet recognized two fatal cases that the media reported recently in Vietnam.Dr. Georg Petersen, a WHO representative in Indonesia, said he was not too worried that the three victims had no known contact with sick birds, because the source of infection is often very hard to find, according to the AP.Petersen said that in view of Indonesia’s history of avian flu outbreaks, the deaths were not a big surprise, according to the AFP report. He added that the three victims “may have had contact with chicken droppings.”Bloomberg News said the three people lived in Tangerang, about 15 miles west of Jarkarta. The report said 1-year-old Thalita Nurul Azizah died Jul 9, followed by her father, Iwan Siswara Rifei, on Jul 12 and her 9-year-old sister, Sabrina Nurul Aisyah, on Jul 14.Supari and Petersen said none of the 315 people who may have had contact with the family have fallen ill, according to the Bloomberg report. The health ministry has taken samples from the contacts and is monitoring them.A veterinary official said all farms within 20 kilometers of the victims’ home were being tested for avian flu, and results were expected back next week, the AP reported.The only previous human case of H5N1 avian flu in Indonesia involved a poultry worker who was tested last March, though he had not been sick. He was found to have a low level of antibodies to the virus, according to results reported in June.Indonesia has had a number of H5N1 outbreaks in poultry, going as far back as August 2003. In May of this year, some pigs in the Tangerang district—the same district where Rifei and his daughters lived—were found to have H5N1 infections without signs of illness. The pigs lived near poultry farms that had been hit by the virus.See also:Indonesia’s report to the World Organization for Animal Health (OIE) on H5N1 infections in pigsftp://ftp.oie.int/AVIAN%20INFLUENZA/infos_san_archives/eng/2005/en_050527v18n21.pdflast_img read more

Firm says ‘universal’ flu vaccine passed early test

first_img “VaxInnate’s M2e universal flu vaccine candidate has passed a critical initial test,” David Taylor, MD, the company’s chief medical officer, said in the news release. “We’re encouraged by these data, which demonstrate that the vaccine is safe and elicits potent immune responses at doses below a microgram [mcg] of vaccine antigen, and does so without the use of conventional adjuvants.” The vaccine, made by VaxInnate Inc., Cranbury, N.J., targets the M2 protein of influenza A viruses, a surface protein that differs little among different strains of type A. Existing flu vaccines target hemagglutinin (HA), a flu surface protein that often mutates, making it necessary to change the vaccine each year to cover the predominant strains in circulation. A vaccine targeting a protein found in all or most flu strains could reduce or eliminate the need to change the vaccine each year. “Should M2e be shown to be protective for influenza A, it’s possible that other universal antigens could be developed for influenza B,” Taylor said in an e-mailed statement. “In the developing world, where influenza vaccine is not available, M2e could be a cost-effective way to provide influenza A coverage. He also commented that VaxInnate is developing seasonal flu vaccines in which its recombinant-bacteria technology is used to make both the A and B components. A vaccine targeting a Solomon Islands strain of H1N1 is currently in clinical testing, and a type B vaccine may become available next year, he said. The two lowest doses were safe and well-tolerated in all the volunteers; they yielded an immune response in 18 of 24 volunteers after the first dose and in 23 of 24 after two doses, VaxInnate said. However, the two highest doses “were associated with the presence of flu-like symptoms in some of the subjects.” Nov 11, 2008 (CIDRAP News) – A vaccine designed to offer protection against many strains of influenza viruses appeared safe in low doses and triggered a satisfactory immune response in a phase 1 clinical trial, the vaccine’s developer announced recently. Plans for targeting type BThe M2e vaccine targets influenza A but not influenza B, the other major type. Type A viruses generally cause more severe illness than type B. Seasonal flu vaccines normally target two type A subtypes—H1N1 and H3N2—and one type B strain, all of which typically circulate each season. “Given the strength of the antibody responses and the absence of significant adverse reactions at the two lowest doses (0.3 and 1.0 mcg), VaxInnate intends to continue development and clinical evaluation of the vaccine candidate at doses of 1.0 mcg and less,” the company said. Flagellin interacts with the immune system’s toll-like receptors, which serve in human immune cells as sentries to detect pathogens and mount a general defense, according to VaxInnate. This initial defense stimulates an adaptive immune response that includes production of pathogen-specific antibodies, the company said. In the trial, 60 healthy volunteers between the ages of 18 and 49 received one of the four doses or a placebo in two injections 28 days apart, the company reported. Safety was assessed 1 and 7 days after immunization, and immune response was examined 7, 14, and 28 days after each dose. Seroconversion was defined as a serum IgG and anti-M2e antibody value of at least 0.174 mcg per milliliter and a fourfold increase in antibody titer. Christine Turley, MD, primary investigator in the study, said in the release that the results for the two lowest doses “suggest that the M2e vaccine candidate could be a promising and much-needed new option for prevention or attenuation of influenza A disease.” She is director of clinical trials and clinical research in the Sealy Center for Vaccine Development, University of Texas Medical Branch (UTMB), Galveston. Fewest events at lowest dosesThe phase 1 trial was a double-blind study designed to test the safety and immunogenicity of four different doses of the vaccine: 0.3, 1, 3, and 10 mcg. It was conducted in Galveston, Tex., and Lenexa, Kan. See also: “The notion of a universal influenza vaccine or any kind of influenza vaccine that reduces the need for annual vaccination or provides better or more reliable protection against influenza viruses—that will be very useful to us,” she said. “Until a vaccine goes all the way through phase 3 clinical trials and we have good evidence about actual protection, the verdict is out. But certainly there are a number of kinds of vaccines in development, such as this one, that are exciting with regard to the prospect of a more universal kind of vaccine.” “VaxInnate is working to develop a second-generation universal vaccine that has M2e and another conserved antigen that will address influenza B strains, as well as influenza A strains. Efficacious universal vaccines for influenza that cover both A and B strains could potentially replace the more standard HA vaccine in some markets and market segments, even in the developed world.” While acknowledging that the M2e vaccine would not cover type B viruses, VaxInnate’s Taylor told CIDRAP News that the company also hopes to develop a second-generation universal vaccine that would target both A and B. Meanwhile, he suggested possible uses for the M2e vaccine by itself, assuming it is successful. Nichol said the measures of immune response used by VaxInnate are reasonable and generally correlate with actual protection, but do not guarantee it. “It’s encouraging but not definitive until we see the clinical protection data,” she said. ‘Encouraging but not definitive’Dr. Kristin Nichol, an experienced flu immunization researcher who was not involved with the study, described VaxInnate’s results as promising but advised a wait-and-see attitude. She is associate chief of staff for research at the Minneapolis VA Medical Center. Taylor also said that in countries where conventional seasonal flu vaccines are available, the M2e vaccine could be used in combination with them to provide increased protection in case the strains in the seasonal vaccine don’t match well with circulating strains. The vaccine consists of the ectodomain of the M2 protein, fused to flagellin, a bacterial protein. The company uses recombinant bacteria to produce the vaccine, a technique that the company says is faster than conventional egg-based production or cell-culture production. The Bill and Melinda Gates Foundation supported the M2e vaccine trial with a $9.5 million grant to UTMB to improve control of flu in the developing world, the company said. The company reported the results in an Oct 26 press release and at the Interscience Conference on Antimicrobial Agents and Chemotherapy/Infectious Diseases Society of America (ICAAC/IDSA) meeting, held Oct 24-28 in Washington, DC. Oct 26 VaxInnate press releasehttp://www.vaxinnate.com/pages/pressreleases/20081026_001.htmllast_img read more

Rodamco in West End deal

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PREMIUMExperts warn of moral hazard, uncertainty as House plans to let BI supervises banks

first_imgFacebook Forgot Password ? LOG INDon’t have an account? Register here The House of Representatives’ proposal to bring back banking supervision to Bank Indonesia (BI) has drawn criticism as experts warn of possible moral hazard and regulatory uncertainty.In a draft revision of the 1999 and 2004 BI laws, the House’s Legislative Body (Baleg) proposed that the central bank take over the job of supervising banks from the Financial Services Authority (OJK). The gradual takeover process is expected to be completed by Dec. 31, 2023, at the latest.The OJK was established in 2011 to oversee the financial industry and it was modeled on the financial services regulatory structure that prevailed in the United Kingdom. It assumed the role of regulator and supervisor of banks in 2013, taking the responsibility from the central bank.The plan to return the role to the central bank will put the credibility of lawmakers and the government at stake, said U… Log in with your social account Google Linkedin Topics : OJK bank-indonesia Financial-Services-Authority BI-Law-revision banking-industry supervisionlast_img read more

Charlie Nicholas tells Unai Emery to bin three Arsenal players and sign PSG star Adrien Rabiot

first_img Comment PSG star Adrien Rabiot would be an ideal signing, says Charlie Nicholas (Picture: Getty)‘In attack, I like Pierre-Emerick Aubameyang and Alexandre Lacazette but will they win you the Premier League? I think they could.‘Between them, bearing in mind they haven’t actually played much together, their goal return has been a very good return.‘Arsenal have been relying on one striker for too long and now they have two so it does give me hope.‘I would sell Henrik Mkhitaryan and if I got the right money for Alex Iwobi I would sell him too. Denis Suarez has gone, that was a waste of time.’Arsenal signed Suarez on loan in January with a view to making his move permanent in the summer. Advertisement Charlie Nicholas tells Unai Emery to bin three Arsenal players and sign PSG star Adrien Rabiot Unai Emery has been urged to offload three Arsenal players (Picture: Getty)Charlie Nicholas has advised Unai Emery to offload three Arsenal players and sign Adrien Rabiot from PSG this summer.The Gunners look set to miss out on a Premier League top-four finish this season but can still qualify for the Champions League by winning the Europa League.Emery’s side secured a 3-1 victory in the first leg of their semi-final clash with Valencia on Thursday and will be confident of progressing to the final.Nicholas says Emery is doing a ‘remarkable’ job at the Emirates but must oversee a major overhaul this summer to ensure the Gunners remain competitive.AdvertisementAdvertisementADVERTISEMENTMore: FootballRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starChelsea defender Fikayo Tomori reveals why he made U-turn over transfer deadline day moveMikel Arteta rates Thomas Partey’s chances of making his Arsenal debut vs Man CityAnd the Arsenal hero thinks Henrik Mkhitaryan, Alex Iwobi and Denis Suarez should all be offloaded, while French World Cup winner Rabiot would be an ideal signing.‘We need a box-to-box style midfield player and a player that can pick a pass too, so it is a matter of bringing in the right ones,’ Nicholas told Sky Sports.‘I think you need to know your system, fit them in and see where it takes you. Adrien Rabiot will be a free-agent and been linked with different clubs, but I would take him.‘He has the quality and is of decent level, which Arsenal need.center_img Emery not taking anything for granted, despite 3-1 lead over ValenciaTo view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Play VideoLoaded: 0%0:00Progress: 0%PlayMuteCurrent Time 0:00/Duration Time 12:27FullscreenEmery not taking anything for granted, despite 3-1 lead over Valenciahttps://metro.co.uk/video/emery-not-taking-granted-despite-3-1-lead-valencia-1917694/This is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.But the Barcelona midfielder has failed to impress Emery and is yet to start a game for the Gunners.Emery replaced Arsene Wenger at the Emirates last summer and Nicholas says the Spaniard is doing a ‘remarkable’ job.He added: ‘It looks like the board have asked Unai Emery to survive to this summer and see whether we can win Europa League or get the top four.‘Emery has done a remarkable job with a bottom-six Premier League defence. He has made mistakes, but who wouldn’t make mistakes with this defence?’More: FootballBruno Fernandes responds to Man Utd bust-up rumours with Ole Gunnar SolskjaerNew Manchester United signing Facundo Pellistri responds to Edinson Cavani praiseArsenal flop Denis Suarez delivers verdict on Thomas Partey and Lucas Torreira moves Metro Sport ReporterFriday 3 May 2019 11:40 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link375Shares Advertisementlast_img read more

Lavish Brisbane sky home sells at a big discount after three years on the market

first_imgThe view from the apartment at 432/30 Macrossan St, Brisbane.A LAVISH sky home in the heart of Brisbane’s CBD has sold for a $775,000 discount after languishing on the market for nearly three years.It’s been a long time coming, but the contemporary apartment in the riverside Admiralty Precinct has finally changed hands for $2.725 million, more than 1000 days after first being listed for sale in August 2015. GET THE LATEST REAL ESTATE NEWS DIRECT TO YOUR INBOX HERE The open plan living space at 432/30 Macrossan St, Brisbane.The master bedroom and three other spacious bedrooms all come with walk-in robes and ensuites.There’s an enormous 44 sqm entertainer’s balcony, a separate entertainment area, large study, plus a bar and wine cellar.The property offers five car spaces and use of the building’s resort-style facilities, including a tennis court, swimming pools, a gym and access to the riverside boardwalk to the Eagle Street Pier. Inside the home at 20 Victoria Pde, Clayfield, which has just sold for $2.25m.The vendor had recently obtained Development Approval for a high-end apartment building, allowing for 11 apartments over five levels. One of the four bedrooms in the apartment at 432/30 Macrossan St, Brisbane.The second biggest sale of the past week according to CoreLogic was a grand, two storey house in one of Clayfield’s most prestigious streets. SOCCEROO SETTLES ON GOLD COAST BEAUTY This property at 20 Victoria Pde, Clayfield, has sold for $2.25m. This apartment at 432/30 Macrossan St, Brisbane, has sold. Picture: realestate.com.au.It was first listed with a price in December 2016, when it was advertised for offers circa $3.5 million.That price was then dropped to between $2.85 and $3.1 million in May 2017, but without any bites the property was eventually listed for ‘all offers considered!’ UNLISTED HOME SETS NEW RECORD center_img Inside the apartment at 432/30 Macrossan St, Brisbane.It was named the top sale of the past week by property researcher, CoreLogic.More from newsParks and wildlife the new lust-haves post coronavirus18 hours agoNoosa’s best beachfront penthouse is about to hit the market18 hours agoThe massive apartment on the 43rd floor at 432/30 Macrossan Street is bigger than most houses, spanning 315 sqm, and offers stunning, uninterrupted views of the Brisbane River, Story Bridge and the city. POWER COUPLE SLASH $3M OFF WATERFRONT MANSION Inside the property at 20 Victoria Pde, Clayfield, which has sold for $2.25m.The property at 20 Victoria Parade comprises a five-bedroom house on an 810 sqm parcel of land over two lots with 20 metre frontage. An artist’s impression of an apartment development proposed for the property at 20 Victoria Pde, Clayfield, which has just sold for $2.25m. An artist’s impression of an apartment project proposed for 20 Victoria Pde, Clayfield.last_img read more

Scott Allen Manis, Sr., 50

first_imgScott Allen Manis, St., 50, of Osgood passed away Sunday, December 4, 2016 at his home. He was born at Covington, Kentucky on September 11, 1966 the son of Donzell and Betty Huff Manis. Survivors include his companion and wife of 25 years Molly Clift Manis; one son Scott (Felisha Gregory) Manis, Jr. of Osgood,; two daughters Kelly Manis of Newport, Kentucky and Chrystal (Brad Yeager) Bushorn of Batesville; 4 grandchildren Elaney McGuire, Evan Yeager, Noelin Manis, and Novah Eaton; two sisters Karla (Greg) Campbell of Aurora and Donna (Mitch) Davis of Milan; two brothers Troy (Kim) Manis of Moores Hill and Donny Manis of Milan. He was preceded in death by his parents, and his granddaughter Ella Rose McGuire. Mr. Manis attended South Dearborn High School with the class of 1985 and graduated from the Greensburg Christian Academy. Scott was a boilermaker and a member of Local 374. His hobbies included fishing, hunting, and camping and he had developed a talent in forging steel and metal. His biggest talent though was joking and making people laugh. Scott also enjoyed doting on his four grandchildren. Funeral services for Scott will be held on Friday, December 9th at 1pm at the Stratton-Karsteter Funeral Home in Versailles with Mark Vice of the New Point Christian Church officiating. Burial will be in the Cliff Hill Cemetery in Versailles. Visitation will be Friday from 11am until time of services. Memorials may be given to the donor’s choice.last_img read more